LcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.
نویسندگان
چکیده
Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.
منابع مشابه
TyeA, a protein involved in control of Yop release and in translocation of Yersinia Yop effectors.
Extracellular Yersinia spp. disarm the immune system by injecting the effector Yersinia outer proteins (Yops) into the target cell. Yop secretion is triggered by contact with eukaryotic cells or by Ca2+ chelation. Two proteins, YopN and LcrG, are known to be involved in Yop-secretion control. Here we describe TyeA, a third protein involved in the control of Yop release. Like YopN, TyeA is local...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 66 6 شماره
صفحات -
تاریخ انتشار 1998